Biosynthetic Gene Cluster Database with Functional Annotations

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Cluster list

MIBiG accession	Biosynthetic class	Organism name	Main product	Genes
BGC0001372	terpene	Penicillium thymicola	penigequinolone A	14

Gene list

Product	Protein ID	UniProt	Domains	Sites	PDB hits	SwissProt hits
PenF	ANY57884.1	A0A1B2CTB3	1	0	0	2

Search results (Top 2)

SwissProt entries

Hit	HSP	RecName	Accession	E value	Identity	Cover	KEGG
1	1	Quinolone epoxide rearrangement protein penF	A0A1B2CTB3	0.00e+00	100.00%	100.00%
1	1	[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone D (RHEA:74491)
2	1	Quinolone epoxide rearrangement protein asqO	P9WEP9	4.84e-142	56.35%	100.00%
		(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone A (RHEA:74511)
		(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone B (RHEA:74515)

Reaction participants

Ligand	Number	Best E value	Name	Formula	PubChem	Structure
CHEBI:193079	1	0.00e+00	[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B	C₂₇H₃₃NO₇
COc1ccc([C@@]2(O)c3c(ccc(/C=C/C(C)(O)CCC4OC4(C)C)c3O)NC(=O)[C@@H]2OC)cc1
CHEBI:193558	1	0.00e+00	yaequinolone D	C₂₇H₃₃NO₇
COc1ccc([C@@]2(O)c3c(ccc(/C=C/C4(C)CCC(C)(C)C(O)O4)c3O)NC(=O)[C@@H]2OC)cc1
CHEBI:193561	2	4.84e-142	(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B	C₂₇H₃₁NO₆
COc1ccc([C@@]2(O)c3c(ccc(/C=C/C(C)=C/CC4OC4(C)C)c3O)NC(=O)[C@@H]2OC)cc1
CHEBI:177743	1	4.84e-142	aspoquinolone A	C₂₇H₃₁NO₆
COc1ccc([C@@]2(O)c3c(ccc(/C=C/[C@@]4(C)OC(C)(C)[C@@H]5C[C@@H]54)c3O)NC(=O)[C@@H] 2OC)cc1
CHEBI:193562	1	4.84e-142	aspoquinolone B	C₂₇H₃₁NO₆
COc1ccc([C@@]2(O)c3c(ccc(/C=C/[C@@]4(C)OC(C)(C)[C@H]5C[C@H]54)c3O)NC(=O)[C@@H]2O C)cc1

Developed by Tohru Terada, Ryota Kobayashi,and Suguru Fujita
Computational Biology Laboratory, Department of Biotechnology, Graduate School of Agricultural and Life Sciences
The University of Tokyo, JAPAN