Biosynthetic Gene Cluster Database with Functional Annotations

Gene cluster information is based on MIBiG Version 4.0 (November 15th, 2024).

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Cluster list

MIBiG accession Biosynthetic class Organism name Main product Genes
BGC0000090PKSActinosynnema pretiosum subsp. pretiosummacbecin, macbecin II23

Gene list

Product Protein ID UniProt Sequence similarity Function prediction
PDB hits SwissProt hits FUJISAN UNKAI
MbcS ACF35462.1 B5A9R6 353 79 0 6
MbcRII ACF35442.1 B5A9P6 0 0 0 4
MbcO ACF35443.1 B5A9P7 16 500 416 562
MbcB ACF35444.1 B5A9P8 0 0 0 0
MbcAI ACF35445.1 B5A9P9 881 2115 0 0
MbcAII ACF35446.1 B5A9Q0 406 1346 0 0
MbcAIII ACF35447.1 B5A9Q1 482 1442 0 0
MbcF ACF35448.1 B5A9Q2 C6W8U8 15 12 0 0
MbcM ACF35449.1 B5A9Q3 26 48 15 6
MbcC ACF35450.1 B5A9Q4 8 49 16 1
MbcD ACF35451.1 B5A9Q5 4 2 1 3
MbcE ACF35452.1 B5A9Q6 C6W8U4 59 90 0 6
MbcL ACF35453.1 B5A9Q7 38 295 341 304
MbcQ ACF35454.1 B5A9Q8 9 41 67 16
MbcN ACF35455.1 B5A9Q9 11 15 1 20
MbcH ACF35456.1 B5A9R0 C6W8T9 0 0 0 0
MbcI ACF35457.1 B5A9R1 75 88 0 0
MbcJ ACF35458.1 B5A9R2 0 0 0 0
MbcK ACF35459.1 B5A9R3 47 219 1 0
MbcG ACF35460.1 B5A9R4 62 70 33 8
MbcP ACF35461.1 B5A9R5 355 90 0 17
MbcT ACF35463.1 B5A9R7 18 90 0 0
MbcU ACF35464.1 B5A9R8 14 125 0 0

Protein interaction network in the cluster

Click to enlarge

Type Protein 1 Protein 2 ipSAE ipSAE_min ipTM
Homo MbcE (ACF35452.1) MbcE (ACF35452.1) 0.87 0.87 0.92
Homo MbcK (ACF35459.1) MbcK (ACF35459.1) 0.84 0.84 0.90
Homo MbcO (ACF35443.1) MbcO (ACF35443.1) 0.81 0.81 0.87
Homo MbcG (ACF35460.1) MbcG (ACF35460.1) 0.75 0.75 0.86
Hetero MbcQ (ACF35454.1) MbcJ (ACF35458.1) 0.78 0.65 0.85
Homo MbcN (ACF35455.1) MbcN (ACF35455.1) 0.76 0.76 0.85
Homo MbcD (ACF35451.1) MbcD (ACF35451.1) 0.73 0.73 0.83
Homo MbcJ (ACF35458.1) MbcJ (ACF35458.1) 0.73 0.73 0.82
Homo MbcQ (ACF35454.1) MbcQ (ACF35454.1) 0.60 0.59 0.78
Homo MbcL (ACF35453.1) MbcL (ACF35453.1) 0.42 0.41 0.77
Hetero MbcI (ACF35457.1) MbcJ (ACF35458.1) 0.61 0.41 0.77
Homo MbcT (ACF35463.1) MbcT (ACF35463.1) 0.49 0.48 0.77
Hetero MbcT (ACF35463.1) MbcU (ACF35464.1) 0.47 0.45 0.74
Hetero MbcJ (ACF35458.1) MbcK (ACF35459.1) 0.33 0.31 0.72
Hetero MbcH (ACF35456.1) MbcJ (ACF35458.1) 0.25 0.22 0.69
Homo MbcI (ACF35457.1) MbcI (ACF35457.1) 0.24 0.24 0.67
Hetero MbcB (ACF35444.1) MbcJ (ACF35458.1) 0.35 0.17 0.64
Hetero MbcB (ACF35444.1) MbcS (ACF35462.1) 0.27 0.11 0.63
Developed by Tohru Terada1, Ryota Kobayashi1, Koutaro Ukai1, Yoshitaka Moriwaki1,2, Leow Chee Siang3, and Suguru Fujita1
1Computational Biology Laboratory, Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, JAPAN
2Computational Drug Discovery and Design Laboratory, Medical Research Laboratory, Institute of Science Tokyo, JAPAN
3Graduate Faculty of Interdisciplinary Research Faculty of Engineering, Mechanical Engineering (Mechatronics), University of Yamanashi, JAPAN